Spondyloarthritis & psoriatic arthritis
Evaluation of spondyloarthritis-specific health utility based on ASAS health index (U-ASAS-HI) among the disease subtypes: an ancillary analysis from the ASAS-PerSpA study
Authors' conclusion
The universal U-ASAS-HI captures the broad range of aspects relevant to valuing SpA health states across SpA subtypes. The lower absolute values of U-ASAS-HI reflect the wider disutility associated with SpA.
Study context
- Population
- Patients in the ASAS-PerSpA study (axSpA, pSpA and psoriatic arthritis (PsA)) who completed both ASAS-HI and EQ-5D-3Lmean age 44
- Participants
- 4,158 patients
- Comparison
- U-ASAS-HI vs EQ-5D-3L utility among spondyloarthritis (SpA) subtypes
Methodological detailsancillary analysis, multivariable linear mixed-effects models with country as level
- Ancillary analysis
- Multivariable linear mixed-effects models with country as level
Primary result
As reported in the abstract
U-ASAS-HI
0.44
mean · SD 0.30
EQ-5D-3L
0.71
mean · SD 0.21
- Correlation between U-ASAS-HI and EQ-5D-3L, consistently strong between subgroups (range)
- 0.74-0.76
Further findings
Determinants of lower U-ASAS-HI (linear mixed-effects model)
- Disease activity (ASDAS), β
- −0.030 (95% CI −0.038 to −0.021)
- Physical function (BASFI), β
- −0.044 (95% CI −0.048 to −0.041)
- Anxiety/depression (EQ-5D-3L q5), β
- −0.147 (95% CI −0.160 to −0.134)
- FM (fibromyalgia rapid screening tool), β
- −0.068 (95% CI −0.083 to −0.053)
- Female gender, PsA subtype, axial involvement, fatigue and no employment associated with lower U-ASAS-HI; older age and university education with higher
Variance attributable to differences between countries (ICC)
- Intraclass correlation coefficient
- 6%
Original publication
Evaluation of spondyloarthritis-specific health utility based on ASAS health index (U-ASAS-HI) among the disease subtypes: an ancillary analysis from the ASAS-PerSpA study. RMD Open. Published 29 October 2025. doi:10.
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