Spondyloarthritis & psoriatic arthritis
Performance of spondyloarthritis-specific health utilities based on the ASAS Health Index: an ancillary analysis from the ASAS-HI validation study
Authors' conclusion
The U-ASAS-HI captures the physical and mental impact of SpA, as well as personal contextual factors such as age, gender and comorbidities. The influence of the country of residence seems negligible.
Study context
- Population
- Spondyloarthritis (SpA) patients who completed the ASAS-HI, EQ-5D-5L and SF-36 questionnaires (mean age 42 years; 65% male)
- Participants
- 1,425 patients
- Comparison
- U-ASAS-HI vs generic utilities
Methodological detailsancillary analysis, linear multivariable mixed-effects model with multilevel modelling fitted by country
- Ancillary analysis
- Linear multivariable mixed-effects model with multilevel modelling fitted by country
Primary result
As reported in the abstract
Mean utility scores
R
0.75
P < 0.001
U-ASAS-HI vs EQ-5D-5L
R
0.72
P < 0.001
U-ASAS-HI vs SF-6D
EQ-5D-5L
0.75
mean · SD 0.11
SF-6D
0.72
mean · SD 0.24
U-ASAS-HI
0.42
mean · SD 0.29
Further findings
Factors associated with U-ASAS-HI (linear mixed-effects model)
- Random effects: intercept SD between countries
- 0.045
- Variance ratio between countries and total U-ASAS-HI variation
- 5.5%
- Worse disease activity (ASDAS) and lower physical function (BASFI) associated with lower U-ASAS-HI
- Younger age, female gender, higher comorbidity score and symptoms of depression associated with lower U-ASAS-HI
- SpA subtype had no influence on health utility
Original publication
Performance of spondyloarthritis-specific health utilities based on the ASAS Health Index: an ancillary analysis from the ASAS-HI validation study. Rheumatology (Oxford). Published 29 January 2025. doi:10.
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