Spondyloarthritis & psoriatic arthritis
Obesity and its associations with clinical manifestations and disease burden of patients with spondyloarthritis: An ancillary study from the ASAS-PerSpA project
Authors' conclusion
Obesity invites a biological therapy burden, work productivity loss, and worse patient-reported health status in patients with SpA.
Study context
- Population
- Patients with SpA in the ASAS-PerSpA cross-sectional study, 24 countries
- Participants
- 4,449 patients24 countries
- Exposure
- Obese vs overweight vs normal-weight patients
- Outcome
- Clinical manifestations and disease burden: btDMARD use and history, SpA-related surgery, work productivity loss and patient-reported health status
Methodological detailsancillary analysis, multinational (24 countries), adjusted for age, gender and smoking
- Ancillary analysis
- Multinational (24 countries)
- Adjusted for age, gender and smoking
Main finding
As reported in the abstract
- Obese/overweight patients had higher btDMARD burden, btDMARD inefficacy, work impairment and worse patient-reported health
- P < 0.05 for all
Observational data: associations, not effects.
Further findings
Comparison by BMI at age 20 years (BMI20y)
- Similar differences found
Original publication
Obesity and its associations with clinical manifestations and disease burden of patients with spondyloarthritis: An ancillary study from the ASAS-PerSpA project. Semin Arthritis Rheum. Published 28 December 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →