Spondyloarthritis & psoriatic arthritis
Association between obesity and likelihood of remission or low disease activity status in psoriatic arthritis applying index-based and patient-based definitions of remission: a cross-sectional study
Authors' conclusion
PsA patients with comorbid obesity were 2.5-3 folds less likely to be in remission/LDA by composite scores compared with non-obese patients; however, remission/LDA rates were similar based on the patients' opinion.
Study context
- Population
- Consecutive adults with definite PsA (disease duration ≥ 2 years) from 14 countries, ReFlaP cohort49.3% women
- Participants
- 431 adults
- Exposure
- Obese vs non-obese patients with PsA
- Obesen = 136
- Outcome
- Remission/LDA (Very Low Disease Activity (VLDA)/minimal disease activity (MDA), Disease Activity in PSoriatic Arthritis (DAPSA) ≤4/≤14, or patients' opinion)
Methodological detailsinternational multicentre, multivariable regression
- International multicentre
- Multivariable regression
Main finding
As reported in the abstract
Remission/LDA by composite scores:
- VLDA
- DAPSA remission
- MDA
Each group vs non-obeseEstimate (95% CI)
Obese
aOR for being in VLDA 0.31(0.13–0.77)
Obese
aOR for being in DAPSA remission 0.39(0.19–0.80)
Obese
aOR for being in MDA 0.61(0.38–0.99)
Observational data: associations, not effects.
Original publication
Association between obesity and likelihood of remission or low disease activity status in psoriatic arthritis applying index-based and patient-based definitions of remission: a cross-sectional study. RMD Open. Published 14 September 2023. doi:10.
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