Spondyloarthritis & psoriatic arthritis
Patient-defined flares and disease activity worsening in 222 patients with psoriatic arthritis from 14 countries
Authors' conclusion
Patient flares were frequent and were associated with active and symptomatic disease.
Study context
- Population
- Consecutive patients with definite psoriatic arthritis (PsA), 14 countries, seen twice in usual care 4.5±2.2 months apart127 (58.8%) males
- Participants
- 222 patients
- Exposure
- Patient-reported flare vs physician-reported flare vs disease activity in psoriatic arthritis (DAPSA) worsening
- Outcome
- Patient-reported flares between the 2 visits (single question), compared with DAPSA worsening (change to a higher DAPSA category)
- Follow-up
- Second visit
Methodological detailsmultinational (14 countries), consecutive patients, usual care
- Multinational (14 countries)
- Consecutive patients
- Usual care
Main finding
As reported in the abstract
Flares / worsening between the 2 visits
- Patient-reported flares
- 27%
- Flares per patient (patients with flare), mean
- 2.2±3.7
- Duration per flare, mean (days)
- 12.6±21.0
- Physician-reported flares
- 17.6%
- DAPSA worsening
- 40.1%
- Agreement between definitions (prevalence adjusted bias adjusted kappa (PABAK)), moderate
- 0.32-0.59
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Disease activity, flare vs no flare (all outcomes)Significantly more active disease in flare | all P<0.001 |
Transition to flare state (patient level)
- Associated with worsening in disease activity and impact outcomes
Original publication
Patient-defined flares and disease activity worsening in 222 patients with psoriatic arthritis from 14 countries. Joint Bone Spine. Published 15 December 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →