Spondyloarthritis & psoriatic arthritis
Transition From Psoriasis to Psoriatic Arthritis is Characterized by Distinct Alterations in Peripheral Blood Tc17, Th17, and CD4 + Effector Memory Cells
Authors' conclusion
Transition from psoriasis to psoriatic arthritis was associated with distinct alterations of the peripheral blood T cell compartment, with Tc17 cells exhibiting the greatest discriminatory power.
Study context
- Population
- Patients with psoriasis at risk of transition, subclinical PsA or definitive PsA
- Participants
- 116 patients
- Exposure
- Psoriasis with risk factor for transition vs subclinical PsA vs definitive PsA
- Outcome
- Peripheral blood T cell compartment
Methodological detailsdeep T cell phenotyping by multicolour flow cytometry, machine-learning techniques
- Deep T cell phenotyping by multicolour flow cytometry
- Machine-learning techniques
Main finding
As reported in the abstract
- Overlapping T cell endotypes; subclinical PsA showed the most notable divergence from the others
- Frequencies of effector memory CD4+ T cells, Th17 and Tc17 cells differed among psoriasis with risk factor, subclinical PsA and PsA
- Transition-associated changes of Tc17 cell frequencies confirmed by machine-learning-assisted unsupervised clustering
Observational data: associations, not effects.
Further findings
- Patients with enthesitis could be distinguished from those without, Tc17 cells being the main distinctive feature
Original publication
Transition From Psoriasis to Psoriatic Arthritis is Characterized by Distinct Alterations in Peripheral Blood Tc17, Th17, and CD4 + Effector Memory Cells. Arthritis Rheumatol. Published 28 December 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →