Spondyloarthritis & psoriatic arthritis
CD3+ immune cell endotypes are associated with psoriatic arthritis (PsA) disease phenotype and response to advanced therapy: an integrated mass cytometry and proteomics cohort study
Authors' conclusion
Heterogeneity in circulating immune cell profiles is associated with PsA clinical features and therapeutic response.
Study context
- Population
- Patients with PsA initiating targeted therapies40 treatment periods
- Participants
- 34 patients
- Exposure
- Circulating CD3+ immune cell endotypes (clusters) compared for clinical features and treatment response
- Outcome
- Immune endotypes and association with clinical features and treatment response
Methodological detailsmass cytometry, hierarchical clustering, generalised estimating equation models, aptamer-based proteomic profiling, imaging mass cytometry
- Mass cytometry
- Hierarchical clustering
- Generalised estimating equation models
- Aptamer-based proteomic profiling
- Imaging mass cytometry
Main finding
As reported in the abstract
- 3 immune clusters identified
- C1 ('memory CD4+ T cell endotype'): higher sonographic musculoskeletal inflammation and peri-articular bone formation, and poorer response to therapy
- C2 ('Nonclassical T cell endotype'): lowest levels of musculoskeletal inflammation
- C3 ('Terminal effector/Th1 cell endotype'): higher sonographic peri-articular inflammation
Observational data: associations, not effects.
Further findings
Stability of immune endotypes · 3 months posttreatment
- Immune endotypes remained relatively stable
Proteomic pathways of the 'memory CD4+ T cell endotype'
- Deregulation of immune-related pathways, incl. several intracellular signalling pathways, most notably WNT signalling
Synovial tissue T cell subsets (imaging mass cytometry)
- CD4+ cells with memory and effector phenotypes abundant in synovial tissue from patients with PsA
Original publication
CD3+ immune cell endotypes are associated with PsA disease phenotype and response to advanced therapy: an integrated mass cytometry and proteomics cohort study. Ann Rheum Dis. Published 8 November 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →