Spondyloarthritis & psoriatic arthritis
Residual activated Th17 cells during low disease activity are associated with disease worsening in radiographic axial spondyloarthritis: A pilot study
Authors' conclusion
Residual activated Th17 cells during inactive disease or LDA are associated with subsequent disease worsening in r-axSpA.
Study context
- Population
- Patients with radiographic axial spondyloarthritis (r-axSpA) in inactive disease or low disease activity (LDA) (ASDAS<2.1)
- Participants
- 21 patients
- Exposure
- Activated Th17-high vs activated Th17-low
- Activated Th17-highn = 9
- Activated Th17-lown = 12reference
- Outcome
- ASDAS trajectory and loss of LDA (ASDAS≥2.1)
- Follow-up
- 6 months
Methodological detailspilot study, ROC-derived cut-off, linear mixed-effects models
- Pilot study
- ROC-derived cut-off
- Linear mixed-effects models
Main finding
As reported in the abstract
Loss of LDA (ASDAS≥2.1)
Activated Th17-high
44.4%
4 of 9
Activated Th17-low
0
events
P < 0.05
- Significantly worse ASDAS trajectory during follow-up in activated Th17-high vs activated Th17-low
- P for interaction < 0.05
Observational data: associations, not effects.
Further findings
Baseline disease activity status (inactive disease [ASDAS<1.3] vs LDA [1.3≤ASDAS<2.1])
- Not associated with differences in ASDAS trajectories
- P for interaction = non-significant
- Not associated with loss of LDA
- P = non-significant
Original publication
Residual activated Th17 cells during low disease activity are associated with disease worsening in radiographic axial spondyloarthritis: A pilot study. Joint Bone Spine. Published 1 September 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →