Spondyloarthritis & psoriatic arthritis
Clinical Expression of Radiographic Axial Spondyloarthritis and Its Association With HLA-B27 in European and Ibero-American Populations
An erratum to this article was published (J Rheumatol, 1 Apr 2025 ↗)
Authors' conclusion
Ibero-American patients with r-axSpA in our study exhibit more peripheral manifestations, more structural damage, and worse functionality than European patients, regardless of the presence of HLA-B27.
Study context
- Population
- Patients with a clinical diagnosis of radiographic axial spondyloarthritis (r-axSpA) fulfilling European Spondyloarthropathy Study Group criteria for SpA, from REGISPONSER and RESPONDIA registries
- Participants
- 2,592 patients
- Exposure
- Ibero-American vs European patients with r-axSpA, stratified by HLA-B27 status
- IBERO-AMERICANn = 1,083
- EUROPEANn = 1,509reference
- Outcome
- Factors independently associated with Ibero-American status, HLA-B27 positive patients
Methodological detailsobservational, multicentre, stratified by HLA-B27 status, multivariate analysis
- Observational
- Multicentre
- Stratified by HLA-B27 status
- Multivariate analysis
Main finding
As reported in the abstract
- Ibero-American vs European
- OR (conventional synthetic disease-modifying antirheumatic drug (csDMARD) intake) 4.21
- Ibero-American vs European
- OR (arthritis) 2.33
- Ibero-American vs European
- OR (enthesitis) 6.01
- Ibero-American vs European
- OR (dactylitis) 6.10
- Ibero-American vs European
- OR (severe structural damage, BASRI) 1.12
- Ibero-American vs European
- OR (poor functionality, BASFI) 1.40
Observational data: associations, not effects.
Further findings
| Outcome | Estimate |
|---|---|
| Factors independently associated with Ibero-American status, HLA-B27 negative patients (multivariate)Ibero-American vs European | OR (enthesitis) 11.67 |
| Factors independently associated with Ibero-American status, HLA-B27 negative patients (multivariate)Ibero-American vs European | OR (csDMARDs) 15.51 |
| Factors independently associated with Ibero-American status, HLA-B27 negative patients (multivariate)Ibero-American vs European | OR (total BASRI) 1.34 |
Clinical manifestations by race
- More arthritis and enthesitis in American Indian patients than in White and Black American patients
Original publication
Clinical Expression of Radiographic Axial Spondyloarthritis and Its Association With HLA-B27 in European and Ibero-American Populations. J Rheumatol. Published 15 January 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →