Spondyloarthritis & psoriatic arthritis
Performance of Disease Activity Indices Used in Axial Spondyloarthritis in Real-World Clinical Settings
Authors' conclusion
The metrological performance of standard disease activity indices in axSpA were similar. The BASDAI values that identify the ASDAS categories are novel.
Study context
- Population
- Patients with axial spondyloarthritis (axSpA) in clinical practice (mean age 47.6 years; median disease duration 8 years; 63.3% on biologic therapies)127 women · 203 men
- Participants
- 330 patients
- Exposure
- BASDAI vs ASDAS vs Bath Ankylosing Spondylitis Functional Index (BASFI) vs ASAS HI
- Outcome
- Performance of disease activity indices: correlations, concordance and discriminating capacity for levels of disease activity and impact
Methodological detailsobservational
- Observational
Main finding
As reported in the abstract
All indices highly correlated (Pearson r)
≥ 0.73
Substantial concordance across activity thresholds and impact categories (κ)
≥ 0.61
Observational data: associations, not effects.
Further findings
| Outcome | BASDAI | ASDAS |
|---|---|---|
| BASDAI cutoffs identifying ASDAS high and very high activity categories | ||
| Cutoff for ASDAS high activity | 3.95 | — not stated in the abstract |
| AUC (high activity) | 0.90 | — not stated in the abstract |
| Cutoff for ASDAS very high activity | 5.85 | — not stated in the abstract |
| AUC (very high activity) | 0.90 | — not stated in the abstract |
| Discrimination of ASAS HI high impact category | ||
| Cutoff | ≥ 3 | ≥ 2.1 |
| AUC | 0.92 | 0.87 |
— not stated in the abstract
Agreement between BASDAI remission (≤ 2) and ASDAS inactive disease (< 1.3)
- Substantial agreement regardless of systemic therapy use
Original publication
Performance of Disease Activity Indices Used in Axial Spondyloarthritis in Real-World Clinical Settings. J Rheumatol. Published 15 January 2025. doi:10.
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