The identification of five latent classes in the REGISPONSER registry with significant overlap between axial and peripheral phenotypes is concordant with a unifying concept of SpA.
Study context
Population
Patients with SpA fulfilling the ESSG criteria in the REGISPONSER registry, 31 specialist centres in Spain
Participants
2,319 patients
Exposure
Axial with spine involvement vs Axial with isolated SI joint involvement vs Axial + peripheral vs Peripheral + psoriasis vs Axial + peripheral + psoriasis
Outcome
Distinct latent classes (phenotypes) of SpA by predefined clinical and radiographic features
Methodological detailslatent class analysis, registry-based, multicentre (31 specialist centres)
Latent class analysis
Registry-based
Multicentre (31 specialist centres)
Main finding
As reported in the abstract
Latent classes of SpA
Five-class latent class analysis (LCA) model yielded the best fit
5
Observational data: associations, not effects.
Original publication
Exploring the unifying concept of spondyloarthritis: a latent class analysis of the REGISPONSER registry. Rheumatology (Oxford). Published 17 January 2024. doi:10.1093/rheumatology/keae005