Spondyloarthritis & psoriatic arthritis
The role of integrated gastro-rheumatological care in IBD-associated Spondyloarthritis in achieving joint–gut remission: Four-year outcomes from the real-world SPIB cohort
Authors' conclusion
The long-term results of the SPIB cohort highlight the value of close collaboration between rheumatologists and gastroenterologists in the application of joint-gut remission strategies.
Study context
- Population
- Consecutive patients with SpA-IBD assessed at a multidisciplinary Gastro-Rheumatological Clinic (SPIB cohort)58% Crohn's disease, 42% ulcerative colitis
- Participants
- 159 patients
- Outcome
- Proportion of patients achieving remission in both intestinal and articular domains
- Follow-up
- Four years
Methodological detailsreal-world, consecutive patients, multidisciplinary gastro-rheumatological clinic, multivariable analysis
- Real-world
- Consecutive patients
- Multidisciplinary gastro-rheumatological clinic
- Multivariable analysis
Main finding
As reported in the abstract
Combined intestinal and articular remission
Combined remission at baseline
0.6%
Combined remission at six months
5.7%
Combined remission at four years
26.3%
Observational data: associations, not effects.
Secondary outcomes
Predictors of remission during follow-up (multivariable)
| OR for remission (95% CI) | ||
|---|---|---|
| Male genderPositive predictor | 2.80 (1.21–6.76) | |
| Axial diseaseNegative predictor | 0.41 (0.17–0.96) | |
| EnthesitisNegative predictor | 0.26 (0.11–0.59) | |
| 0.10.31310OR for remission (log scale) |
Combined intestinal and articular remission, earlier time points · baseline; 6 months
- Combined remission at baseline
- 0.6%
- Combined remission at six months
- 5.7%
Change in disease activity scores · 4 years
- TJC
- Δ-3.8
- SJC
- Δ-1.0
- LEI score
- Δ-0.3
- DAPSA remission status
- +36.0%
- ASDAS inactive disease status
- +38.0%
- CDAI remission status
- +19.3%
- pMayo remission status
- +26.2%
Treatment patterns · 2 years
- bDMARD therapy increased by
- 36%
- Corticosteroid use decreased by
- 35%
Original publication
The role of integrated gastro-rheumatological care in IBD-associated Spondyloarthritis in achieving joint–gut remission: Four-year outcomes from the real-world SPIB cohort. Semin Arthritis Rheum. Published 3 June 2026. doi:10.
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