Spondyloarthritis & psoriatic arthritis
Cycling versus swapping strategies for treatment of psoriatic arthritis after primary tumour necrosis factor inhibitors failure: a systematic review and meta-analysis
Authors' conclusion
Following TNFi failure, cycling and swapping strategies show comparable retention and safety
Study context
- Population
- Patients with PsA after primary TNF inhibitors (TNFi) failure
- Participants
- 2,300 patients5 observational studies
- Comparison
- Cycling to another TNFi vs swapping to a bDMARD with a different mechanism after TNFi failure
- Cyclingn = 1,517
- Swappingn = 783reference
- Outcome
- Lack of response
Pooled result
As reported in the abstract
- No significant difference between groups
Further pooled results
12-month retention
- No significant difference between groups
24-month retention
- No significant difference between groups
Safety
Adverse events
- No significant difference between groups
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Cycling versus swapping strategies for treatment of psoriatic arthritis after primary tumour necrosis factor inhibitors failure: a systematic review and meta-analysis. Rheumatology (Oxford). Published 29 May 2026. doi:10.
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