Spondyloarthritis & psoriatic arthritis
Effect of apremilast on whole-body magnetic resonance imaging of peripheral and axial inflammation in patients with psoriatic arthritis
Authors' conclusion
Apremilast reduced both peripheral and axial inflammation in patients with PsA.
Study context
- Population
- Patients with psoriatic arthritis (PsA), 29 global locations122 treated and analysed
- Participants
- 123 patients
- Comparison
- Apremilast 30 mg twice daily ± concomitant stable MTX for 48 weeks; change from baseline
- Apremilastn = 122
- Primary endpoint
- Change from baseline in axial or peripheral inflammation by whole-body magnetic resonance imaging (WB-MRI) (secondary and post hoc outcomes)
- Follow-up
- Weeks 24 and 48
Methodological detailsphase 4, multicentre, open-label, post hoc analyses
- Phase 4
- Multicentre
- Open-label
- Post hoc analyses
Primary result
As reported in the abstract
WB-MRI inflammation, LS mean change from baseline
- Total (peripheral + axial) inflammation, week 24
- −3.6 [−6.3, −0.9] (95% CI)
- Total (peripheral + axial) inflammation, week 48
- −3.9 [−7.1, −0.6] (95% CI)
- Total peripheral inflammation, week 24
- −3.5 [−5.5, −1.5] (95% CI)
- Total peripheral inflammation, week 48
- −4.1 [−6.4, −1.7] (95% CI)
- Peripheral joint inflammation (WIPE method), week 24
- −3.4 [−5.1, −1.7] (95% CI)
- Peripheral joint inflammation (WIPE method), week 48
- −3.6 [−5.7, −1.5] (95% CI)
- Spine inflammatory lesions (Canada-Denmark method), week 24
- −2.6 [−3.6, −1.5] (95% CI)
- Spine inflammatory lesions (Canada-Denmark method), week 48
- −2.1 [−3.7, −0.6] (95% CI)
Further findings
MRI inflammation by baseline disease activity (post hoc)
- Decreases more prominent with moderate vs high baseline disease activity
- Post hoc analyses
Original publication
Effect of apremilast on whole-body magnetic resonance imaging of peripheral and axial inflammation in patients with psoriatic arthritis. Ann Rheum Dis. Published 27 May 2026. doi:10.
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