Spondyloarthritis & psoriatic arthritis
Clinical phenotypes and therapeutic outcomes in enteropathic arthritis: a multivariate analysis from a retrospective cohort
Authors' conclusion
The significantly higher likelihood of developing enthesitis in IBD-first suggests that distinct disease onset patterns and clinical phenotypes may influence musculoskeletal manifestations and treatment responses in enteropathic arthritis.
Study context
- Population
- Patients with SpA-IBD evaluated by both rheumatologists and gastroenterologists at a multidisciplinary ImmunoCenter, March 2022 to March 2024
- Participants
- 66 patients
- Exposure
- Inflammatory bowel diseases (IBD)-first vs spondyloarthritis (SpA)-first presentation of enteropathic arthritis
- IBD-firstn = 47
- SpA-firstn = 19reference
- Outcome
- Associations between disease onset and specific musculoskeletal manifestations; predictors of therapeutic multi-failure
Methodological detailsmultidisciplinary ImmunoCenter, multivariate logistic regression
- Multidisciplinary ImmunoCenter
- Multivariate logistic regression
Main finding
As reported in the abstract
Enthesitis at SpA onset
P = 0.021
Observational data: associations, not effects.
Further findings
Enthesitis during follow-up
P = 0.034
Axial involvement
Peripheral involvement
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Developing enthesitis, multivariate logistic regression adjusted for confoundersAdjusted for confounders | 0.267 (0.076–0.942) | P = 0.040 | |
| 0.050.21520Odds ratio (log scale) |
Therapeutic multi-failure: psoriasis as predictor
| OR (95% CI) | P value | ||
|---|---|---|---|
| Psoriasis | 6.39 (1.60–25.47) | P = 0.009 | |
| 0.050.21520Odds ratio (log scale) |
- Developing enthesitis, multivariate logistic regression adjusted for confounders: IBD-first reported as associated with a higher likelihood of enthesitis
Axial involvement
- No significant difference
Peripheral involvement
- No significant difference
Laboratory parameters
- No significant differences between the two groups
Therapeutic multi-failure: psoriasis as predictor
- Other phenotypic features not significantly predictive
Original publication
Clinical phenotypes and therapeutic outcomes in enteropathic arthritis: a multivariate analysis from a retrospective cohort. Clin Exp Rheumatol. Published 20 December 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →