Spondyloarthritis & psoriatic arthritis
Physical function and sex differences in radiographic axial spondyloarthritis: a cross-sectional analysis on Bath Ankylosing Spondylitis Functional Index
Authors' conclusion
No difference between male and female r-axSpA patients was seen in BASFI despite significant sex differences in BASMI, mSASSS, and CRP levels.
Study context
- Population
- Patients with radiographic axial spondyloarthritis patients (r-axSpA) fulfilling the modified New York criteria for AS (mean age 52.2 ± 12.7 years, 62.3% males)
- Participants
- 353 patients
- Exposure
- Males vs females with r-axSpA
- Outcome
- Factors associated with BASFI, overall and by sex
Methodological detailsobservational, multivariable linear regression
- Observational
- Multivariable linear regression
Main finding
As reported in the abstract
BASFI score
Males
2.7
± 2.0
Females
2.9
± 2.1
- Age, BMI, ASDAS-CRP, Bath Ankylosing Spondylitis Metrology Index (BASMI) or Modified Stoke Ankylosing Spondylitis Spinal Score (mSASSS), fatigue and tenderness independently associated with Bath Ankylosing Spondylitis Functional Index (BASFI) in different models (R2)
- 0.53-0.63
Observational data: associations, not effects.
Further findings
| Outcome | Males | Females | P value |
|---|---|---|---|
| BASFI question: ability to look over shoulder (worse in males) | mean 4.43 ± 3.37 | mean 3.74 ± 3.06 | P = 0.05 |
| BASFI question: ability to climb stairs (worse in females) | mean 1.54 ± 2.32 | mean 2.49 ± 2.77 | P < 0.001 |
- BASFI question: ability to look over shoulder (worse in males) — Correlation with mSASSS (r)
- 0.53
- BASFI question: ability to look over shoulder (worse in males) — Correlation with BASMI (r)
- 0.62
- BASFI question: ability to look over shoulder (worse in males): strongest correlations with mSASSS and BASMI among separate BASFI questions, p < 0.001 each
Original publication
Physical function and sex differences in radiographic axial spondyloarthritis: a cross-sectional analysis on Bath Ankylosing Spondylitis Functional Index. Arthritis Res Ther. Published 26 September 2023. doi:10.
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