Identification and characteristics of patients with axial psoriatic arthritis: clinical, phenotypic and imaging associations

Vassilakis, KD; Papagoras, C; Gazi, S; Mole, E; Krikelis, M; Voulgari, PV; Kaltsonoudis, E; Koletsos, N; Katsimpri, P; Boumpas, D; Katsifis-Nezis, D; Kougkas, N; Boutel, M; Dimitroulas, T; Sfikakis, PP; Tektonidou, MG; Galani, A; Michalakeas, N; Bogdanos, DP; Simopoulou, T; Koutsianas, C; Mavrea, E; Katsifis, G; Kottas, K; Konsta, M; Kataxaki, E; Kalavri, E; Klavdianou, K; Sfontouris, C; Daoussis, D; Iliopoulos, G; Bournazos, I; Karokis, D; Georganas, C; Patrikos, D; Vassilopoulos, D; Fragoulis, GE

doi:10.1093/rheumatology/keaf137

Spondyloarthritis & psoriatic arthritis

Identification and characteristics of patients with axial psoriatic arthritis: clinical, phenotypic and imaging associations

Rheumatology (Oxford)Published 8 Mar 2025Cross-sectional study

Read the original article ↗PubMed

Cite

Authors' conclusion

Approximately one-quarter of patients with PsA exhibit axial involvement, and among them, ∼30% have isolated spinal axPsA and nr-axPsA, respectively.

Study context

Population: Patients with psoriatic arthritis (PsA) from the Greek-multicentre PsA study
Participants: 922 patients

Exposure: Axial PsA (axPsA) vs non-axPsA; sacroiliac vs spinal axPsA; nr-axPsA vs r-axPsA
axPsAn = 238
Sacroiliac axPsAn = 101
Spinal axPsAn = 75reference
Outcome: Frequency and clinical and imaging characteristics of axPsA

Methodological detailsmulticentre

Multicentre

Main finding

As reported in the abstract

Prevalence of axPsA

axPsA

25.8%

238

Observational data: associations, not effects.

Further findings

Subtypes among axPsA

Sacroiliac axPsA42%

Spinal axPsA32%

nr-axPsA35%

Outcome	← Lower odds ←→ Higher odds →	OR (95% CI)
Factors associated with sacroiliacvs spinal axPsAAge (younger)	0.10.31310	0.97 (0.94–0.99)
Factors associated with sacroiliacvs spinal axPsAEnthesitis at diagnosis	0.10.31310	3.37 (1.66–6.82)
Factors associated with nr-axPsA vs r-axPsAnr-axPsAvs r-axPsAFemale sex	0.10.31310	2.59 (1.39–4.82)
Factors associated with nr-axPsA vs r-axPsAnr-axPsAvs r-axPsAAge (younger)	0.10.31310	0.96 (0.94–0.99)
	0.10.31310Odds ratio (log scale)

Reference

Authors: Vassilakis KD, Papagoras C, Gazi S, Mole E, Krikelis M, Voulgari PV, et al.
All 37 authors
Vassilakis KD, Papagoras C, Gazi S, Mole E, Krikelis M, Voulgari PV, Kaltsonoudis E, Koletsos N, Katsimpri P, Boumpas D, Katsifis-Nezis D, Kougkas N, Boutel M, Dimitroulas T, Sfikakis PP, Tektonidou MG, Galani A, Michalakeas N, Bogdanos DP, Simopoulou T, Koutsianas C, Mavrea E, Katsifis G, Kottas K, Konsta M, Kataxaki E, Kalavri E, Klavdianou K, Sfontouris C, Daoussis D, Iliopoulos G, Bournazos I, Karokis D, Georganas C, Patrikos D, Vassilopoulos D, Fragoulis GE
Journal: Rheumatology (Oxford)
Published: 8 Mar 2025
DOI: 10.1093/rheumatology/keaf137
PubMed: 40059325

Topic: Spondyloarthritis & psoriatic arthritis

Exposure definitions

axPsA: PsA (CASPAR criteria) with inflammatory back pain (present or ever) and positive imaging of the sacroiliac joints and/or spine (MRI or X-rays)
sacroiliac axPsA: isolated sacroiliac joint involvement
spinal axPsA: isolated involvement of the rest of the spine
nr-axPsA: positive MRI findings only
r-axPsA: positive X-ray findings

Key notes

axPsA vs non-axPsA: less frequent peripheral arthritis at diagnosis; increased rates of HLA-B27 positivity, enthesitis ever and inflammatory bowel disease

Original publication

Identification and characteristics of patients with axial psoriatic arthritis: clinical, phenotypic and imaging associations. Rheumatology (Oxford). Published 8 March 2025. doi:10.1093/rheumatology/keaf137

Read the original article ↗

Composed by AI from the published abstract and checked against it. How Briefs are made →