Spondyloarthritis & psoriatic arthritis
Evaluation of concomitant peripheral arthritis in early axial spondyloarthritis: results from a 24 month follow-up (Italian arm of SPACE study)
Authors' conclusion
axSpA patients with PA more often had other peripheral manifestations and increased disease activity and functional impairment, and revealed possible differences in axial involvement.
Study context
- Population
- Patients with chronic back pain (duration ≥3 months and ≤2 years; age of onset <45 years), Italian SPACE cohort; Axial spondyloarthritis (axSpA) diagnosed by MRI and X-rays of the sacroiliac joints83.5% nr-axSpA
- Participants
- 91 patients
- Exposure
- axSpA with peripheral arthritis (PA) vs axSpA without PA
- Outcome
- Associations between PA, clinical and disease activity indices, and imaging features in early axSpA
Methodological details24-month follow-up, Italian arm of SPACE cohort, baseline data analysis, multivariable logistic regression
- 24-month follow-up
- Italian arm of SPACE cohort
- Baseline data analysis
- Multivariable logistic regression
Main finding
As reported in the abstract
Baseline features associated with PA
- PA prevalence among axSpA
- 44%
- HLA-B27 positivity, PA vs no PA
- 35% vs 43.1%; p = 0.02
- Uveitis, PA vs no PA
- 5% vs 9.8%; p = 0.03
- Dactylitis, PA vs no PA
- 37.5% vs 0%; p < 0.01
- Enthesitis, PA vs no PA
- 82.5% vs 56.9%; p = 0.02
- PA independently associated with higher baseline CRP (multivariable)
- p = 0.004
- PA independently associated with dactylitis (multivariable)
- p = 0.02
Observational data: associations, not effects.
Further findings
Functional and disease activity indices over 24 months · 12 and 24 months
- Functional and disease activity indices improved overall
Original publication
Evaluation of concomitant peripheral arthritis in early axial spondyloarthritis: results from a 24 month follow-up (Italian arm of SPACE study). Scand J Rheumatol. Published 24 February 2026. doi:10.
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