Spondyloarthritis & psoriatic arthritis
Decreased expression of NAT10 in peripheral blood mononuclear cells from new-onset ankylosing spondylitis and its clinical significance
Authors' conclusion
The present study suggested that the decreased mRNA NAT10 may play a role in AS pathogenesis and predictive model based on mRNA NAT10 and N% act as bioindicator for forecast and progression of diseases.
Study context
- Population
- Patients with new-onset ankylosing spondylitis (AS), healthy controls, and patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), The First Afliated Hospital of Nanchang University
- Participants
- 56 / 52 / 20 / 16
- Comparison
- Peripheral blood mononuclear cell (PBMC) NAT10 mRNA expression in new-onset AS vs healthy controls (HC), RA and SLE
- New-Onset ASn = 56
- HCn = 52reference
- RAn = 20
- SLEn = 16
- Outcome
- NAT10 mRNA expression in PBMC and diagnostic performance
Methodological detailscase-control, single-centre
- Case-control
- Single-centre
Performance
As reported in the abstract
Predictive model (NAT10 mRNA + N%), AS vs HC: AUC
0.880
Predictive model, AS vs HC: sensitivity
84.62%
Predictive model, AS vs HC: specificity
76.92%
Further findings
Predictive model, new-onset AS vs RA and SLE
- AUC
- 0.661
- Sensitivity
- 90.38%
- Specificity
- 47.22%
Predictive model + HLA-B27 vs HLA-B27 alone, AS vs HC
- Model + HLA-B27 sensitivity (39/42)
- 92.86%
- Model + HLA-B27 specificity (52/52)
- 100.00%
- Model + HLA-B27 accuracy (91/94)
- 96.81%
- HLA-B27 sensitivity (38/45)
- 84.44%
- HLA-B27 specificity (52/52)
- 100.00%
- HLA-B27 accuracy (90/97)
- 92.78%
- Combination superior to HLA-B27
Original publication
Decreased expression of NAT10 in peripheral blood mononuclear cells from new-onset ankylosing spondylitis and its clinical significance. Arthritis Res Ther. Published 2 January 2024. doi:10.
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