Spondyloarthritis & psoriatic arthritis
IL-17-producing cells in ankylosing spondylitis patients show gender-based differences in gene expression
Authors' conclusion
Transcriptomic analysis revealed that male AS patients exhibit distinct expression patterns of IL-17 pro-inflammatory genes, which may contribute to the phenotypic differences observed between genders in AS.
Study context
- Population
- Ankylosing Spondylitis (AS) patients at the Clinical Research Unit of MetroHealth Medical Center
- Participants
- 11 vs 10
- Comparison
- Male vs female AS patients: transcriptome of stimulated IL-17-enriched peripheral blood mononuclear cells (PBMCs)
- Malen = 11
- Femalen = 10reference
- Outcome
- Gene expression (transcriptome) of IL-17-enriched PBMCs stimulated with CytoStim, focus on inflammatory cytokine genes
Methodological detailsRNA-sequencing, transcriptomic comparison
- RNA-sequencing
- Transcriptomic comparison
Main finding
As reported in the abstract
Differential gene expression, male vs female AS patients
Genes identified by RNA-sequencing (RNA-seq)
12,893
Genes with p-values <0.05, distinct expression between male and female
2,851
Original publication
IL-17-producing cells in ankylosing spondylitis patients show gender-based differences in gene expression. Clin Exp Rheumatol. Published 21 June 2023. doi:10.
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