Spondyloarthritis & psoriatic arthritis
WTAP regulates PTEN through m6A methylation to modulate the inflammatory response in CD4+ T cells from patients with ankylosing spondylitis
Authors' conclusion
In conclusion, WTAP downregulation promotes AS inflammation by decreasing PTEN expression through an m6A-dependent mechanism.
Study context
- Population
- Ankylosing spondylitis (AS) patients and age- and gender-matched healthy controls; CD4+ T lymphocytes from peripheral venous blood; WTAP-knockdown model in human Jurkat T cells45 AS patients and 45 healthy controls
- Participants
- 45 vs 45
- Comparison
- AS patients compared to healthy controls; WTAP knockdown in Jurkat T cells
- AS PATIENTSn = 45
- HEALTHY CONTROLSn = 45
- Outcome
- WTAP and PTEN expression levels in CD4+ T lymphocytes
Methodological detailsage- and gender-matched
- Age- and gender-matched
Main finding
As reported in the abstract
- Significantly downregulated in AS patients compared to healthy controls
Observational data: associations, not effects.
Further findings
Correlation of WTAP and PTEN with TNF-α levels
- Both inversely correlated with TNF-α levels
PTEN expression, PTEN m6A modification and TNF-α expression after WTAP knockdown in Jurkat T cells
- Marked decrease in both PTEN expression and its m6A modification, coinciding with a significant increase in TNF-α expression
Original publication
WTAP regulates PTEN through m6A methylation to modulate the inflammatory response in CD4+ T cells from patients with ankylosing spondylitis. Clin Exp Rheumatol. Published 30 June 2026. doi:10.
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