Spondyloarthritis & psoriatic arthritis
Ten-year clinical outcome of recent-onset axial spondyloarthritis: Results from the DESIR inception Cohort
Authors' conclusion
These findings suggest that despite a quite favorable 10-year outcome exists for severe outcomes, a large proportion of patients present with an important disease burden reflected by patient-reported outcomes.
Study context
- Population
- Patients with recent-onset axial spondyloarthritis (axSpA) (DESIR inception cohort)enrolled
- Participants
- 708 patients
- Outcome
- 10-year clinical outcome
- Follow-up
- 10 years
Methodological detailscomplete cases and imputed data analyses, 45 excluded due to change in baseline diagnosis; 300 lost to follow-up over 10 years
- Complete cases and imputed data analyses
- 45 excluded due to change in baseline diagnosis; 300 lost to follow-up over 10 years
Main finding
As reported in the abstract
Acceptable PASS, estimated proportion
70%
95% CI 63; 77
BASDAI<3, estimated proportion
43%
95% CI 37; 49
ASDAS<2.1, estimated proportion
48%
95% CI 41; 56
Observational data: associations, not effects.
Further findings
Severe outcomes (completer population) · 10 years
- Bilateral total hip replacement, patients
- 1
- Pension due to invalidity, patients
- 56
- Completer population
Prevalence of extra-musculoskeletal features, baseline to year 10
- Psoriasis, baseline → year 10
- 18% to 30%
- Acute anterior uveitis, baseline → year 10
- 10% to 18%
- Inflammatory bowel disease, baseline → year 10
- 5% to 10%
Hypertension (most frequent comorbidity), baseline to year 10
- Hypertension, baseline → year 10
- 5% to 15%
Deaths · 10 years
- Patients died
- 3
Original publication
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