Spondyloarthritis & psoriatic arthritis
Nonsteroidal anti-inflammatory drug use and incident hypertension in axial spondyloarthritis: Data from des Spondylarthopathies Indifférenciées Récentes (DESIR) cohort
Main finding · Incident hypertension with NSAID use (time-varying)Result — go to the resultHazard ratio 1.01 95% CI 1.00–1.02Authors' conclusion
In this axSpA inception cohort, we found no significant association between NSAID use and the development of hypertension.
Study context
- Population
- Patients with recent onset axial spondyloarthritis (axSpA) without baseline hypertension, DESIR cohort (mean age 33 years, 54% female)88 incident hypertension
- Participants
- 631 patients
- Exposure
- High-dose NSAID use vs low/no use
- High-dosen = 247
- Outcome
- Incident hypertension (association with time-varying NSAID use; main analysis)
Methodological detailsinception cohort, Cox proportional hazards models with time-varying NSAID exposure, confounder adjustment
- Inception cohort
- Cox proportional hazards models with time-varying NSAID exposure
- Confounder adjustment
Main finding
As reported in the abstract
Incident hypertension with NSAID use (time-varying) · 10-year follow-up
Hazard ratio
1.01
95% CI 1.00–1.02
High-dose NSAID use (ASAS NSAID index ≥50)vs low/no use
HR 1.01 (95% CI 1.00–1.02)
Observational data: associations, not effects.
Original publication
Nonsteroidal anti-inflammatory drug use and incident hypertension in axial spondyloarthritis: Data from DESIR cohort. Joint Bone Spine. Published 25 March 2026. doi:10.
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