Spondyloarthritis & psoriatic arthritis
Influence of Sex on Early Axial Spondyloarthritis: A Six‐Year Longitudinal Analysis From a Large National Cohort
Authors' conclusion
In early axial SpA, clinical outcomes (disease activity and symptoms) were worse in women than men over 6 years of follow-up, whereas CRP was similar and structural damage was more frequent in men.
Study context
- Population
- Patients with recent axial spondyloarthritis (SpA) (<3 years of disease, DMARD-naive, fulfilling ASAS classification criteria), French multicentre DESIR cohort50.4% men
- Participants
- 494 patients
- Exposure
- Women vs men
- Outcome
- Sex differences in disease outcomes: ASDAS-CRP, PtGA, CRP level and radiographic sacroiliitis over time
- Follow-up
- 6 years
Methodological detailsmulticentre, longitudinal, linear and logistic mixed-effects models, k-means trajectory modelling
- Multicentre
- Longitudinal
- Linear and logistic mixed-effects models
- K-means trajectory modelling
Main finding
As reported in the abstract
ASDAS-CRP, PtGA, CRP and structural damage over 6 years
- Both men and women showed clear improvements in ASDAS-CRP, patient global assessment (PtGA) and CRP level over 6 years
- Women vs Men: P < 0.0001
- Women vs Men: P = 0.089
- Men vs Women: P < 0.0001
Observational data: associations, not effects.
Further findings
Persistent high/very high disease activity trajectories · 6 years
Persistent high/very high disease activity trajectories · 6 years
- ASDAS-CRP globally higher in women in these trajectories
Original publication
Influence of Sex on Early Axial Spondyloarthritis: A Six‐Year Longitudinal Analysis From a Large National Cohort. Arthritis Care Res (Hoboken). Published 15 March 2023. doi:10.
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