Spondyloarthritis & psoriatic arthritis

Comparison of established and preliminarily proposed ASAS MRI working group cut-offs for inflammatory MRI lesions in the sacroiliac joints in radiographic and non-radiographic axial spondyloarthritis

RMD OpenPublished Post hoc analysis of part A of the C-OPTIMISE phase 3 open-label study

Authors' conclusion

This analysis suggests that the preliminary 2021 cut-offs for MRI inflammatory lesions may slightly increase the specificity of the quantitative part of the 2009 MRI inflammatory lesion definition.

Study context

Population
Axial spondyloarthritis (axSpA) (radiographic and non-radiographic) patients treated with certolizumab pegol
Participants
657 participants
Comparison
2009 vs preliminary 2021 ASAS MRI inflammatory cut-offs for MRI+/MRI- classification, by clinical outcomes on certolizumab pegol
  • Discordantn = 53

Primary result

As reported in the abstract

Clinical outcomes (ASAS40, ASDAS, BASDAI) by MRI cut-off subgroup · to week 48

Discordant

8.1%

53

Original publication

Comparison of established and preliminarily proposed ASAS MRI working group cut-offs for inflammatory MRI lesions in the sacroiliac joints in radiographic and non-radiographic axial spondyloarthritis. RMD Open. Published 3 September 2024. doi:10.1136/rmdopen-2023-003886

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