Spondyloarthritis & psoriatic arthritis
Defining and validating a high specificity MRI cut-off for the radiographic part of the modified New York criteria in patients with axial spondyloarthritis
Authors' conclusion
A composite MRI-score based on assessing erosion, backfill and ankylosis for five predefined semicoronal SIJ slices (CSDS5) was the optimal high specificity MRI cut-off to rad-mNYc positivity
Study context
- Population
- Patients diagnosed with axSpA with available sacroiliac joint (SIJ) MRI and radiograph, five European clinical registries (EuroSpA Collaboration)296 (46%) rad-mNYc positive
- Participants
- 640 patients
- Comparison
- MRI structural cut-offs vs radiographic component of the modified New York criteria (mNYc)
- Outcome
- MRI cut-offs with 95% specificity for rad-mNYc positivity
Methodological detailsmulticentre (five European clinical registries, EuroSpA Collaboration), internal validation by bootstrapping
- Multicentre (five European clinical registries, EuroSpA Collaboration)
- Internal validation by bootstrapping
Performance
As reported in the abstract
CSDS5 cut-off ≥ 30 predicting rad-mNYc
| Test or model | Specificity | Sensitivity | AUC | Accuracy with mNYc |
|---|---|---|---|---|
| CSDS5 | 0.95 | 0.39 | 0.83 | 69.2% |
CSDS5
Specificity0.95
Sensitivity0.39
AUC0.83
Accuracy with mNYc69.2%
Further findings
| Outcome | Sclerosis | Erosion | Backfill | Ankylosis |
|---|---|---|---|---|
| Individual lesion cut-offs predicting rad-mNYc | ||||
| Sensitivity | ≤ 0.21 | ≤ 0.21 | ≤ 0.21 | 0.34 |
| Accuracy | ≈60% | ≈60% | ≈60% | 67% |
Cut-offs using all MRI slices
- Performed slightly worse or similarly
Original publication
Defining and validating a high specificity MRI cut-off for the radiographic part of the modified New York criteria in patients with axial spondyloarthritis. Arthritis Res Ther. Published 17 July 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →