Spondyloarthritis & psoriatic arthritis
Liver fibrosis and steatosis in psoriatic arthritis: A real-world elastography-based study
Authors' conclusion
These findings indicate a dissociation between hepatic steatosis and fibrosis in treated PsA and support the predominant role of metabolic factors in shaping hepatic involvement.
Study context
- Population
- Patients with PsA under active follow-up at a tertiary hospital receiving b/tsDMARDs120 underwent vibration-controlled transient elastography (VCTE)
- Participants
- 198 patients
- Outcome
- Prevalence of clinically significant liver fibrosis (BMI-adjusted liver stiffness thresholds)
Methodological detailssingle tertiary hospital, guideline-based sequential screening algorithm, vibration-controlled transient elastography (VCTE), multivariable analyses
- Single tertiary hospital
- Guideline-based sequential screening algorithm
- Vibration-controlled transient elastography (VCTE)
- Multivariable analyses
Main finding
As reported in the abstract
Clinically significant liver fibrosis (BMI-adjusted liver stiffness thresholds)
Clinically significant fibrosis using BMI-adjusted thresholds
4 patients
2.0%
Observational data: associations, not effects.
Further findings
Clinically significant fibrosis using a ≥7.0 kPa cut-off
- Clinically significant fibrosis using a≥7.0kPa cut-off
- 6 (3.0%)
Intermediate or high risk on sequential screening, underwent VCTE
- Classified as intermediate or high risk and underwent VCTE
- 120 (60.6%)
Hepatic steatosis (CAP≥248dB/m)
- Hepatic steatosis present
- 63.3%
Liver stiffness
- Median liver stiffness
- 4.1kPa (IQR 3.5-5.2)
Associations with liver stiffness and steatosis (multivariable analyses)
- Inflammatory disease activity not associated with liver stiffness or steatosis
- Age showed a modest association with liver stiffness
- BMI strongly associated with steatosis but not with fibrosis
- MTX exposure not associated with liver fibrosis or steatosis
Original publication
Liver fibrosis and steatosis in psoriatic arthritis: A real-world elastography-based study. Joint Bone Spine. Published 15 July 2026. doi:10.
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