Spondyloarthritis & psoriatic arthritis
Associations of Physical Activity Levels With Depressive Symptoms Among Patients With Radiographic Axial Spondyloarthritis: A Cross-Sectional Study
Authors' conclusion
Moderate-level PA was associated with a lower prevalence of depressive symptoms in patients with r-axSpA, whereas associations for high-level PA were less consistent.
Study context
- Population
- Patients with radiographic axial spondyloarthritis (r-axSpA) identified from the UK Biobank
- Participants
- 1,542 patients
- Exposure
- Moderate- and high-level vs low-level physical activity
- Outcome
- Depressive symptoms (Patient Health Questionnaire (PHQ-2))
Methodological detailsUK Biobank, multivariable logistic regression
- UK Biobank
- Multivariable logistic regression
Main finding
As reported in the abstract
Depressive symptoms, by total PA level (fully adjusted)
Each group vs low-level TPAOdds ratio (95% CI)
Moderate-level TPA
0.55(0.36–0.82)
High-level TPA
0.63(0.39–1.01)
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| Depressive symptoms, by leisure-time PA level (fully adjusted)Moderate-level LTPAvs Low-level TPA | 0.58 (0.34–0.996) | |
| 0.20.5125Odds ratio (log scale) |
Depressive symptoms, by leisure-time physical activity (PA) level (fully adjusted)
- Low- and high-level leisure-time PA (LTPA) showed no significant associations after full adjustment
Original publication
Associations of Physical Activity Levels With Depressive Symptoms Among Patients With Radiographic Axial Spondyloarthritis: A Cross-Sectional Study. J Rheumatol. Published 15 July 2026. doi:10.
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