Spondyloarthritis & psoriatic arthritis
Effect of depressive symptoms on treatment response in patients with axial spondyloarthritis (axSpA): data from the RABBIT-SpA register
Authors' conclusion
Depressive symptoms have a significant and independent negative effect on treatment response in patients with axSpA, particularly in achieving LDA and ID.
Study context
- Population
- Patients with axSpA starting a new systemic therapy, RABBIT-SpA register
- Participants
- 1,755 patients
- Exposure
- Moderate-to-severe depressive symptoms (WHO-5 <29) vs no or mild symptoms at baseline
- Outcome
- LDA and ID (ASDAS-CRP)
- Follow-up
- 3 and 6 months
Methodological detailslongitudinal, observational register (RABBIT-SpA), logistic regression adjusted for confounders selected via a directed acyclic graph, multiple imputation
- Longitudinal, observational register (RABBIT-SpA)
- Logistic regression adjusted for confounders selected via a directed acyclic graph
- Multiple imputation
Main finding
As reported in the abstract
LDA or ID (ASDAS-CRP)
- Fewer patients with moderate-to-severe depressive symptoms reached low disease activity (LDA) or inactive disease (ID) at 3 and 6 months vs no or mild symptoms
- Depressive symptoms associated with lower odds of reaching LDA or ID at both time points (logistic regression)
Observational data: associations, not effects.
Further findings
Prevalence of moderate-to-severe depressive symptoms at baseline
- Moderate-to-severe depressive symptoms at baseline
- 29%
Original publication
Effect of depressive symptoms on treatment response in patients with axSpA: data from the RABBIT-SpA register. RMD Open. Published 8 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →