Spondyloarthritis & psoriatic arthritis
Proteomic and genomic profiling of plasma exosomes from patients with ankylosing spondylitis
An erratum to this article was published (Ann Rheum Dis, 15 Feb 2024 ↗)
Authors' conclusion
Individuals with AS have different immunological and genetic profiles, as determined by evaluating the exosomes of these patients. The inhibitory effect of exosomes on Treg in AS suggests a mechanism contributing to chronically activated T cells in this disease.
Study context
- Population
- Patients with ankylosing spondylitis (AS) and healthy controls (HC); plasma-derived exosomes
- Comparison
- Plasma-derived exosomes from patients with AS vs HC
- Outcome
- Exosome proteomic, cytokine and miRNA profiles and effects on CD4+ T cells
Methodological detailscase-control comparison, proteomic and miRNA profiling, in vitro coculture
- Case-control comparison
- Proteomic and miRNA profiling
- In vitro coculture
Main finding
As reported in the abstract
- Exosome marker proteins CD63 and CD81 elevated in AS vs HC
- q<0.05
- Downregulation of IL-8 and IL-10 in plasma-derived AS-exosomes
- q<0.05
- AS-exosomes cocultured with HC CD4+ T cells induced significant upregulation of IFNα2 and IL-33
- q<0.05
- Differentially expressed microRNAs (miRNAs) in circulating exosomes, AS vs HC
- 24
- miRNAs upregulated
- 22
- miRNAs downregulated
- 2
Original publication
Proteomic and genomic profiling of plasma exosomes from patients with ankylosing spondylitis. Ann Rheum Dis. Published 2 August 2023. doi:10.
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