Spondyloarthritis & psoriatic arthritis
Treatment satisfaction, disease severity, and health-care use in patients with axial spondyloarthritis in the United States and Europe
Authors' conclusion
Differences in symptomatic burden and care were observed between regions.
Study context
- Population
- Consecutive patients with axial SpA (axSpA) reported by rheumatologists in the USA and 5EU, March–November 2021349 rheumatologists
- Participants
- 2,750 patients
- Exposure
- USA vs five European countries
- USAn = 656
- 5EUn = 2,094reference
Methodological detailsreal-world survey, Adelphi axSpA Disease Specific Programme, multinational (USA and 5EU), 1011 (36.8%) patients self-reported data, Alignment quantified using weighted kappa
- Real-world survey
- Adelphi axSpA Disease Specific Programme
- Multinational (USA and 5EU)
- 1011 (36.8%) patients self-reported data
- Alignment quantified using weighted kappa
Main finding
As reported in the abstract
- Symptomatic burden and care differed between regions
Observational data: associations, not effects.
Further findings
| Outcome | USA | 5EU | P value |
|---|---|---|---|
| Number of symptoms at diagnosisMean | 6.0 (SD 4.4) | 6.4 (SD 4.3) | P = 0.0657 |
| Number of symptoms at data collectionMean | 3.3 (SD 3.3) | 2.3 (SD 2.8) | P < 0.0001 |
| Physician-patient alignment (weighted kappa) | |||
| κ, severity at diagnosis | 0.37 | 0.47 | |
| κ, severity at treatment initiation | 0.32 | 0.42 | |
| κ, severity at data collection | 0.32 | 0.61 | |
| κ, treatment satisfaction | 0.35 | 0.42 | |
| Consultations in previous 12 monthsMean | 5.2 (SD 3.4) | 6.5 (SD 5.1) | P = 0.0008 |
Physician-patient alignment (weighted kappa)
- Alignment lower in the USA than in 5EU
Consultations in previous 12 months
- Mean hospitalizations similar
Original publication
Treatment satisfaction, disease severity, and health-care use in patients with axial spondyloarthritis in the United States and Europe. Rheumatology (Oxford). Published 20 March 2026. doi:10.
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