Spondyloarthritis & psoriatic arthritis
Spondyloarthritis Preceding and Following Inflammatory Bowel Disease Diagnosis and Risk Factors: A Temporal Trends Analysis in a Population‐Based Cohort
Authors' conclusion
In a population-based cohort, we report that SpA diagnosis is associated with IBD preceding and following its diagnosis.
Study context
- Population
- Nationwide population-based cohort, January 1, 1998 to July 31, 2022: individuals with inflammatory bowel disease (IBD) and matched individuals without IBD17,108 (16.7%) with IBD
- Participants
- 102,648 participants
- Exposure
- Individuals with IBD vs matched individuals without IBD
- IBDn = 17,108
- Outcome
- SpA prevalence preceding IBD diagnosis (odds) and new-onset SpA incidence following IBD diagnosis (hazard)
Methodological detailsnationwide, cross-linked register data, logistic regression, Cox regression
- Nationwide
- Cross-linked register data
- Logistic regression
- Cox regression
Main finding
As reported in the abstract
SpA in the eight-year period preceding diagnosis
Each group vs matched individualsAdjusted odds ratio (95% CI)
IBD
1.95(1.78–2.14)
CD
2.84(2.43–3.32)
UC
1.61(1.43–1.81)
Observational data: associations, not effects.
Further findings
| Outcome | aHR (95% CI) | |
|---|---|---|
| New-onset SpA following diagnosisIBDvs Matched individuals | 2.51 (2.34–2.70) | |
| New-onset SpA following diagnosisCDvs Matched individuals | 3.17 (2.81–3.59) | |
| New-onset SpA following diagnosisUCvs Matched individuals | 2.24 (2.05–2.45) | |
| 0.20.5125Adjusted hazard ratio (log scale) |
Temporal trends and subgroups
- Spondyloarthritides (SpA) prevalence showed temporal variability, increasing in the few years around IBD diagnosis
- Associations stronger for axial SpA and among women and young adults following IBD diagnosis
Original publication
Spondyloarthritis Preceding and Following Inflammatory Bowel Disease Diagnosis and Risk Factors: A Temporal Trends Analysis in a Population‐Based Cohort. Arthritis Rheumatol. Published 18 March 2026. doi:10.
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