Spondyloarthritis & psoriatic arthritis
Anti-Integrin αvβ6 Autoantibodies as a Biomarker for Ulcerative Colitis in Patients With Axial Spondyloarthritis
Authors' conclusion
Anti-αvβ6 positivity demonstrated potential as a diagnostic test for UC in patients with axSpA, particularly those with a family history of IBD.
Study context
- Population
- Patients with axial spondyloarthritis (axSpA) with or without concurrent inflammatory bowel disease (IBD), and healthy controls
- Participants
- 18 / 29 / 48 / 48
- Comparison
- Anti-αvβ6 in axSpA with ulcerative colitis (UC) vs axSpA with Crohn disease (CD) vs axSpA alone vs healthy controls
- axSpA and UCn = 18
- axSpA and CDn = 29
- axSpA alonen = 48reference
- Healthy controls (HCs)n = 48
- Outcome
- Anti-αvβ6 for the diagnosis of UC among patients with axSpA
Methodological detailsELISA, serial samples
- ELISA
- Serial samples
Performance
As reported in the abstract
Anti-αvβ6 for diagnosis of UC in axSpA
| Test or model | Sensitivity | Specificity | AUC |
|---|---|---|---|
| Anti-αvβ6 | 55.6% | 89.6% | 0.83 |
Anti-αvβ6
Sensitivity55.6%
Specificity89.6%
AUC0.83
Further findings
Anti-αvβ6 positivity and family history of IBD (axSpA and UC)
- Anti-αvβ6 positivity was associated with a family history of IBD in patients with axSpA and UC
Serial samples: anti-αvβ6 status transitions
- Anti-αvβ6-positive patients who became anti-αvβ6-negative
- 3 of 10
- Anti-αvβ6-negative to anti-αvβ6-positive transitions were not observed
CRP and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) by anti-αvβ6 status
- Anti-αvβ6-positive patients had decreased mean CRP and BASDAI scores vs anti-αvβ6-negative patients
Original publication
Anti-Integrin αvβ6 Autoantibodies as a Biomarker for Ulcerative Colitis in Patients With Axial Spondyloarthritis. J Rheumatol. Published 15 September 2025. doi:10.
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