Spondyloarthritis & psoriatic arthritis
Inflammation assessment in psoriatic arthritis via optical spectral transmission: correlations with clinical markers and musculoskeletal ultrasound
Authors' conclusion
OST associated significantly with clinical, US and laboratory disease activity markers in patients with PsA. Furthermore, OST could reliably differentiate between sonographically inflamed and non-inflamed joints in patients with PsA.
Study context
- Population
- Patients with PsA and healthy controls; finger (MCP, PIP, DIP) and wrist joints3,000 joints per group
- Participants
- 100 vs 100
- Comparison
- PsA patients vs healthy controls, optical spectral transmission (OST) of finger and wrist joints
- PsAn = 100
- Controlsn = 100reference
- Outcome
- OST in detecting joint inflammation in PsA (OST values, diagnostic performance by ROC)
Methodological detailscase-control, subset with musculoskeletal ultrasound (US), ROC analysis, correlation analyses and linear regression
- Case-control
- Subset with musculoskeletal US
- ROC analysis
- Correlation analyses and linear regression
Performance
As reported in the abstract
OST value; diagnostic performance (ROC, PsA vs controls)
| Test or model | Value | AUC | Sensitivity | Specificity | OST cut-off |
|---|---|---|---|---|---|
| PsA | 15.76 | 0.848 (95%-CI 0.795-0.900; p<0.001) | 0.89 | 0.71 | 12.75 |
| Controls | 10.24 |
Value
PsA15.76
Controls10.24
AUC
PsA0.848 (95%-CI 0.795-0.900; p<0.001)
Controls— not stated in the abstract
Sensitivity
PsA0.89
Controls— not stated in the abstract
Specificity
PsA0.71
Controls— not stated in the abstract
OST cut-off
PsA12.75
Controls— not stated in the abstract
- PsA vs Controls: P < 0.001 — OST significantly higher in PsA
Further findings
Correlations of OST with US and disease activity markers among patients
- Joint power Doppler US (rho; p)
- rho=0.412; p=0.015
- Grey-scale US (rho; p)
- rho=0.419; p=0.014
- CRP (rho; p)
- rho=0.232; p=0.021
- Disease-Activity-in-Psoriatic-Arthritis (DAPSA) (rho; p)
- rho=0.215; p=0.032
- DAS28 (rho; p)
- rho=0.23; p=0.021
Original publication
Inflammation assessment in psoriatic arthritis via optical spectral transmission: correlations with clinical markers and musculoskeletal ultrasound. Rheumatology (Oxford). Published 11 September 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →