Spondyloarthritis & psoriatic arthritis
Bacterial translocation and intestinal permeability in early axial spondyloarthritis association with 5-year outcomes: insights from the DESIR cohort
Authors' conclusion
PLTP activity is a promising biomarker associated with SI joint inflammation and radiographic progression over 5 years in recent axSpA.
Study context
- Population
- Patients with early axial spondyloarthritis (axSpA) in the DESIR cohort with clinical data available at 5 years
- Participants
- 297 patients
- Exposure
- Baseline serological markers of intestinal permeability (zonulin) and bacterial translocation (3-hydroxymyristate, phospholipid transferase protein (PLTP)) vs extra-musculoskeletal manifestations (EMMs) and radiographic progression at 5 years
- Outcome
- Presence of EMM and imaging SI scores as outcomes of disease progression
- Follow-up
- 5 years
Methodological detailsunivariate and multivariate logistic regression
- Univariate and multivariate logistic regression
Main finding
As reported in the abstract
Association of baseline markers with disease progression at 5 years
PLTP activity higher with radiographic sacroiliitis progression vs without (nmol/h/ml)
6.1 vs 5.2
P = 0.02
PLTP activity and radiographic sacroiliitis progression, after adjustment (β)
0.27
P = 0.02
Observational data: associations, not effects.
Further findings
Baseline zonulin with vs without baseline radiographic sacroiliitis (ng/ml)
- Zonulin lower with baseline radiographic sacroiliitis
- 88.1 vs 140.6 ng/ml, P < 0.001
- Not confirmed in multivariate linear regression
PLTP activity and baseline SPARCC SI joint score
- Positive correlation (β)
- 0.61, P = 0.02
- Adjusted for age, sex and CRP (β)
- 0.58, P = 0.03
Original publication
Bacterial translocation and intestinal permeability in early axial spondyloarthritis association with 5-year outcomes: insights from the DESIR cohort. Rheumatology (Oxford). Published 22 April 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →