Spondyloarthritis & psoriatic arthritis
Functional Impact of Structural Damage in Psoriatic Arthritis: Insights from a Prospective Cohort Study
Authors' conclusion
Radiographic structural damage, particularly severe joint destruction, is independently associated with impaired PF in PsA
Study context
- Population
- Patients with psoriatic arthritis (PsA) in a large longitudinal cohort (mean ± SD age 44.61 ± 12.76 years; 55.8% men)
- Participants
- 1,177 patients
- Outcome
- Association between radiographic structural damage (mSS, 0-168) and physical function (HAQ, 0-3; SF-36 PF subscale, 0-100)
Methodological detailslongitudinal, linear mixed models
- Longitudinal
- Linear mixed models
Main finding
As reported in the abstract
Higher modified Steinbrocker score (mSS) and worse SF-36 physical function (PF), β
−0.10
95% CI −0.15 to −0.05
Higher mSS and worse Health Assessment Questionnaire (HAQ), β
0.003
95% CI 0.002 to 0.004
Observational data: associations, not effects.
Further findings
Baseline values (median, IQR)
- mSS (IQR 0-8.5)
- 2
- HAQ (IQR 0.12-1.12)
- 0.62
- SF-36 PF (IQR 35-85)
- 60
Number of damaged joints (grade 2-4) and physical function
- Worse SF-36 PF, β
- −0.23 (95% CI −0.38 to −0.08)
- Worse HAQ, β
- 0.005 (95% CI 0.002 to 0.009)
Presence of a damaged joint (grade 2-4) and physical function
- Presence of a damaged joint (grade 2-4) alone did not impact PF
Presence of a joint with grade 4 destruction and physical function
- Worse SF-36 PF, β
- −3.04 (95% CI −5.93 to −0.15)
- Worse HAQ, β
- 0.09 (95% CI 0.03 to 0.15)
Count of grade 4 joints (dose response) and physical function
- SF-36 PF, β
- −0.54 (95% CI −0.81 to −0.26)
- HAQ, β
- 0.01 (95% CI 0.01 to 0.02)
Original publication
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