Spondyloarthritis & psoriatic arthritis
Diagnostic delay is associated with uveitis and inflammatory bowel disease in AS: a study of extra-musculoskeletal manifestations in SpA
Authors' conclusion
EMMs are more prevalent in AS than PsA and often present before the onset of the articular disease. A longer diagnostic delay is associated with the 'de novo' appearance of uveitis and IBD in AS
Study context
- Population
- Patients with AS and PsA from two single-centre European cohorts and one multicentre Latin American cohort (RESPONDIA)
- Participants
- 3,553 patients
- Exposure
- Diagnostic delay ≥5 years vs shorter delay; AS vs PsA
- ASn = 2,097
- PsAn = 1,456
- Outcome
- Prevalence of EMMs (uveitis, IBD, psoriasis) and association between diagnostic delay and EMM incidence
Methodological detailstwo single-centre cohorts in Europe and one multicentre cohort in Latin America (RESPONDIA), direct standardization, Cox proportional hazard analysis
- Two single-centre cohorts in Europe and one multicentre cohort in Latin America (RESPONDIA)
- Direct standardization
- Cox proportional hazard analysis
Main finding
As reported in the abstract
Overall prevalence of EMMs
| Group | Value | Uveitis | IBD | Psoriasis |
|---|---|---|---|---|
| AS | 22.9% (95% CI 21.1–24.8) | 22.9% (95% CI: 21.1, 24.8) | 8.1% (95% CI: 7.0, 9.4) | 11.0% (95% CI: 9.7, 12.4) |
| PsA | 3.8% (95% CI 2.9–5.0) | 3.8% (95% CI: 2.9, 5.0) | 2.1% (1.3, 2.9) | 94.6% (93.0, 95.9) |
Value
AS22.9% (95% CI 21.1–24.8)
PsA3.8% (95% CI 2.9–5.0)
Uveitis
AS22.9% (95% CI: 21.1, 24.8)
PsA3.8% (95% CI: 2.9, 5.0)
IBD
AS8.1% (95% CI: 7.0, 9.4)
PsA2.1% (1.3, 2.9)
Psoriasis
AS11.0% (95% CI: 9.7, 12.4)
PsA94.6% (93.0, 95.9)
Observational data: associations, not effects.
Further findings
Extra-musculoskeletal manifestations (EMM) incidence with diagnostic delay ≥5 years, AS (multivariable model)
| Estimate | ||
|---|---|---|
| Diagnostic delay ≥5 years | HR (uveitis) 4.01 (95% CI 3.23–4.07) | |
| Diagnostic delay ≥5 years | HR (IBD) 1.85 (95% CI 1.28–2.67) | |
| 0.20.5125Ratio (log scale) |
EMM incidence with diagnostic delay, PsA (multivariable model)
| Estimate | ||
|---|---|---|
| Diagnostic delay | HR (uveitis) 1.57 (95% CI 0.69–3.59) | |
| Diagnostic delay | HR (IBD) 1.59 (95% CI 0.39–6.37) | |
| 0.10.31310Ratio (log scale) |
EMM presenting before arthritis
Uveitis
IBD
Original publication
Diagnostic delay is associated with uveitis and inflammatory bowel disease in AS: a study of extra-musculoskeletal manifestations in SpA. Rheumatology (Oxford). Published 15 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →