Spondyloarthritis & psoriatic arthritis
Methotrexate treatment in early psoriatic arthritis in comparison to rheumatoid arthritis: an observational nationwide study
Authors' conclusion
In Swedish clinical practice, methotrexate use is similar in PsA and RA, both regarding initiation of other DMARDs and methotrexate retention.
Study context
- Population
- Patients with disease-modifying antirheumatic drug (DMARD)-naïve, newly diagnosed psoriatic arthritis (PsA) starting MTX 2011–2019, Swedish national registers, matched 1:1 to rheumatoid arthritis (RA)
- Participants
- 3,642 vs 3,642
- Exposure
- Newly diagnosed PsA vs RA starting MTX
- PsAn = 3,642
- RAn = 3,642reference
- Outcome
- Proportions remaining on MTX and not having started another DMARD within 2 years of starting MTX
- Follow-up
- 2 years
Methodological detailsnationwide Swedish registers, logistic regression, non-responder imputation
- Nationwide Swedish registers
- Logistic regression
- Non-responder imputation
Main finding
As reported in the abstract
Remaining on MTX
Observational data: associations, not effects.
Further findings
Not started any other DMARD · 2 years after MTX start
Not started a biological or targeted synthetic DMARD · 2 years after MTX start
| Outcome | PsA | RA | Estimate | |
|---|---|---|---|---|
| Pain score ≤15 mm on MTX monotherapy · 6 monthsNon-responder imputation | 26% | 36% | aOR for achieving pain score ≤15 mm 0.63 (95% CI 0.47–0.85) | |
| Global health ≤20 mm on MTX monotherapy · 6 monthsNon-responder imputation | 32% | 42% | aOR for achieving global health ≤20 mm 0.57 (95% CI 0.42–0.76) | |
| Evaluator-assessed 'remission' on MTX monotherapy · 6 monthsNon-responder imputation | 20% | 27% | aOR for achieving evaluator-assessed 'remission' 0.54 (95% CI 0.39–0.75) | |
| 0.20.5125Ratio (log scale) |
Original publication
Methotrexate treatment in early psoriatic arthritis in comparison to rheumatoid arthritis: an observational nationwide study. RMD Open. Published 12 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →