Spondyloarthritis & psoriatic arthritis
Association of Higher Levels of High‐Sensitivity C‐Reactive Protein With Future Development of Psoriatic Arthritis in Psoriasis: A Prospective Cohort Study
Main finding · Incident PsA per higher baseline hsCRP (multivariable)Result — go to the resultHazard ratio 1.04 95% CI 1.01–1.07Authors' conclusion
Higher levels of systemic inflammation, as measured by hsCRP levels, are associated with future development of PsA.
Study context
- Population
- Patients with psoriasis without psoriatic arthritis (PsA) at enrollment, observed 2006–201957 developed PsA
- Participants
- 589 patients
- Exposure
- Baseline high-sensitivity C-reactive protein (hsCRP) levels and risk of incident PsA
- Outcome
- Development of PsA
Methodological detailsmultivariable Cox proportional hazards model, annual rheumatologist assessment
- Multivariable Cox proportional hazards model
- Annual rheumatologist assessment
Main finding
As reported in the abstract
Incident PsA per higher baseline hsCRP (multivariable)
Hazard ratio
1.04
95% CI 1.01–1.07
P = 0.007
Higher hsCRP
HR 1.04 (95% CI 1.01–1.07); P = 0.007
Per higher baseline hsCRP, as printed
Observational data: associations, not effects.
Further findings
Baseline hsCRP level
Baseline hsCRP by patient characteristics
- Significantly higher hsCRP in patients with arthralgia, obesity, and in women
hsCRP–PsA association by sex and body mass index (BMI)
- Similar effect size in men and women; no significant interaction between hsCRP and sex or BMI
Original publication
Association of Higher Levels of High‐Sensitivity C‐Reactive Protein With Future Development of Psoriatic Arthritis in Psoriasis: A Prospective Cohort Study. Arthritis Care Res (Hoboken). Published 19 May 2025. doi:10.
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