Spondyloarthritis & psoriatic arthritis
Psoriatic dactylitis: the association with human leukocyte antigen (HLA) genetic susceptibility markers
Authors' conclusion
HLA-B*27 and -C*02 and the HLA-B*27/C*02 haplotype are associated with PsA dactylitis. HLA-B*27 may also influence the resolution of tender dactylitis.
Study context
- Population
- Patients with psoriatic arthritis (PsA) followed at an observational cohort
- Participants
- 1,216 patients
- Exposure
- Carriers vs non-carriers of HLA-B and -C alleles and common haplotypes
- Outcome
- Dactylitis; time to resolution of the first tender dactylitis episode
Methodological detailslongitudinal, logistic regression with generalised estimating equations, Cox regression adjusted for confounders
- Longitudinal
- Logistic regression with generalised estimating equations
- Cox regression adjusted for confounders
Main finding
As reported in the abstract
Dactylitis (observed in 584 [48%] patients; median follow-up 12.0 years, IQR 5.7-20.1)
- HLA-B*27, OR (95% CI 1.49-2.53), higher risk
- 1.94
- HLA-C*02, OR (95% CI 1.17-2.25), higher risk
- 1.63
- HLA-B*27/C*02 haplotype, OR (95% CI 1.32-2.67), higher risk
- 1.88
- HLA-B*15, OR (95% CI 0.54-0.98), lower risk
- 0.72
- HLA-C*12, OR (95% CI 0.97-1.62), weaker association
- 1.25
- HLA-B*27/C*01 haplotype, OR (95% CI 0.99-2.00), weaker association
- 1.40
Observational data: associations, not effects.
Further findings
Time to resolution of first tender dactylitis episode
- HLA-B*27, HR (95% CI 0.57-0.96), slower resolution
- 0.74
- Cox regression adjusted for confounders
Original publication
Psoriatic dactylitis: the association with HLA genetic susceptibility markers. Ann Rheum Dis. Published 5 March 2026. doi:10.
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