Spondyloarthritis & psoriatic arthritis
GITR/GITRL interaction promotes the expansion of T helper 9 and T helper 17 in psoriatic arthritis
Authors' conclusion
Our results suggest a novel role of GITR/GITRL in promoting the expansion of Th9 and Th17 in PsA-inflamed tissues.
Study context
- Population
- Patients with active psoriatic arthritis (PsA) naive to DMARDs; peripheral blood, synovial fluid (SF), synovial and ileal samples
- Comparison
- PsA patients vs healthy subjects and OA patients
- PsAn = 21
Methodological detailsflow cytometry, in vitro functional assay with recombinant GITR agonist, immunofluorescence of synovial and ileal biopsies
- Flow cytometry
- In vitro functional assay with recombinant GITR agonist
- Immunofluorescence of synovial and ileal biopsies
Main finding
As reported in the abstract
- Increased in vitro expression of GITR on CD4+ T cells and GITRL on antigen-presenting cells in PsA peripheral blood
- GITR agonist in vitro increased expansion of Th9 and Th17 cells
- Increased GITR and GITRL expression also in PsA SF, synovium and ileum
Original publication
GITR/GITRL interaction promotes the expansion of T helper 9 and T helper 17 in psoriatic arthritis. Clin Exp Rheumatol. Published 2 November 2024. doi:10.
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