Lupus & antiphospholipid syndrome
The impact of pregnancy planning and medical readiness on reproductive outcomes in women with systemic lupus erythematosus
Authors' conclusion
The HOP-STEP Intervention effectively identified pregnancy interest, giving rheumatologists the opportunity to address patient reproductive goals, optimize disease activity, and adjust medication regimens prior to conception.
Study context
- Population
- Adult females in a prospective registry meeting American College of Rheumatology (ACR) or SLICC criteria for systemic lupus erythematosus (SLE)
- Exposure
- Healthy Outcomes in Pregnancy with SLE Through Education of Providers (HOP-STEP) Intervention across two time periods (2/2018-12/2019 vs 10/2020-4/2021), in-person vs virtual visits
- Outcome
- Interest in pregnancy
Methodological detailspre- and post-pandemic periods, some visits via telehealth
- Pre- and post-pandemic periods
- Some visits via telehealth
Main finding
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Second time period, in-person | Second time period, virtual | P value |
|---|---|---|---|
| Pregnancy interest assessed, in-person vs virtual visits | 90% | 67% | P = 0.02 |
- Conception in women not medically ready for pregnancy and not on effective contraception: Not medically ready, no effective contraception 5.8%
- Conception in women not medically ready for pregnancy and not on effective contraception: 52 women in both time periods
Contraceptive use with teratogen use or increased SLE activity
- Not significantly different during either time period
Pregnancy in women using moderate or highly effective contraception
- None became pregnant
- 0
Pregnancy outcomes, unintended or high-risk vs well-timed pregnancies
- Similar
Original publication
The impact of pregnancy planning and medical readiness on reproductive outcomes in women with systemic lupus erythematosus. Lupus. Published 15 November 2023. doi:10.
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