Lupus & antiphospholipid syndrome
Validation of eight endotypes of lupus based on whole-blood RNA profiles
Authors' conclusion
The identification of eight molecular endotypes of lupus based on whole blood gene expression was validated in an independent data set of diverse patients.
Study context
- Population
- Patients meeting American College of Rheumatology (ACR) or SLICC criteria for SLE classification participating in three clinical trials; whole blood obtained at baseline
- Participants
- 101 patients3 clinical trials
- Outcome
- Molecular endotypes of SLE based on whole-blood RNA profiles
- Follow-up
- Baseline
Methodological detailsprospective application in an independent set of patients, random forest algorithm, gene set variation analysis, ridge logistic regression
- Prospective application in an independent set of patients
- Random forest algorithm
- Gene set variation analysis
- Ridge logistic regression
Performance
As reported in the abstract
- Patients with SLE were subset into eight endotypes identified by the algorithm
- 8
Original publication
Validation of eight endotypes of lupus based on whole-blood RNA profiles. Lupus Sci Med. Published 13 May 2025. doi:10.
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