Vasculitis & polymyalgia rheumatica
The correlation of endoplasmic reticulum aminopeptidase 1 polymorphisms with Behçet's disease: a meta-analysis
Authors' conclusion
The present meta-analysis prompted the heterogeneous influences of ERAP1 polymorphisms on BD development, which were malleable under the discrepancies in genetic grounds and disease diagnoses.
Study context
- Population
- Studies of ERAP1 polymorphisms in Behçet's disease (BD) and healthy controls
- Comparison
- BD vs healthy controls, by ERAP1 polymorphism
- Outcome
- Association of ERAP1 polymorphisms with BD risk (pooled odds ratios (ORs) with 95% confidence intervals (CIs))
Pooled result
As reported in the abstract
ERAP1 polymorphisms and BD susceptibility
- rs10050860, rs17482078, rs2287987, rs1065407 and rs72773968 presented pathogenic influence
- rs26618 acted out beneficial function
- rs27044, rs26653, rs27895 and rs3734016 had no pronounced biological significance
- Effect of rs30187 not yet determined
Further pooled results
Subgroup by race
- Mongolian were more susceptible to suffering from BD than Caucasian
Subgroup by diagnostic criteria
- International Study Group criteria slightly attenuated the pathogenicity of ERAP1 polymorphisms vs International Criteria for Behçet's Disease
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
The correlation of endoplasmic reticulum aminopeptidase 1 polymorphisms with Behçet's disease: a meta-analysis. Clin Exp Rheumatol. Published 30 November 2022. doi:10.
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