Vasculitis & polymyalgia rheumatica
Ocular manifestations of ANCA-associated vasculitis
Authors' conclusion
Ocular manifestations occur in all forms of AAV, especially in GPA.
Study context
- Population
- Individuals with ANCA-associated vasculitis (AAV) in longitudinal multicentre cohorts followed between 2006 and 2022
- Participants
- 1,441 individuals
- Exposure
- Eosinophilic granulomatosis with polyangiitis (EGPA) vs granulomatosis with polyangiitis (GPA) vs microscopic polyangiitis (MPA)
- EGPAn = 395
- GPAn = 876
- MPAn = 170
- Outcome
- Ocular manifestations at any time in the disease course
Methodological detailslongitudinal, multicentre, univariate and multivariable logistic regression
- Longitudinal
- Multicentre
- Univariate and multivariable logistic regression
Main finding
As reported in the abstract
- Ocular manifestations, all patients
- 23.1%
Observational data: associations, not effects.
Further findings
Ocular manifestations at onset vs during follow-up
- At onset (n)
- 224
- During follow-up (n)
- 120
Most common disease-related manifestations
- Conjunctivitis/episcleritis and scleritis
Associations in multivariable analysis
- Dacryocystitis, lacrimal duct obstruction and retro-orbital disease associated with sinonasal manifestations of GPA
- Ocular manifestations associated with hearing loss in MPA
Most common ocular complications and/or damage
- Cataracts (n)
- 168
- Visual impairment (n)
- 195
Original publication
Ocular manifestations of ANCA-associated vasculitis. Rheumatology (Oxford). Published 28 November 2022. doi:10.
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