Vasculitis & polymyalgia rheumatica
Modification of 2022 ACR/EULAR anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis classification criteria in a Japanese cohort (J-CANVAS)
Authors' conclusion
The modified criteria improved the accuracy of AAV classification in Japanese patients.
Study context
- Population
- Japanese patients with microscopic polyangiitis (MPA), granulomatosis with polyangiitis (GPA) and eosinophilic granulomatosis with polyangiitis (EGPA) in the J-CANVAS registry
- Comparison
- Modified 2022 ACR/EULAR AAV classification criteria vs original 2022 ACR/EULAR criteria
- Outcome
- Classification accuracy (sensitivity and specificity) for MPA, GPA and EGPA
Methodological detailsmulticentre, retrospective cohort
- Multicentre
- Retrospective cohort
Performance
As reported in the abstract
Sensitivity and specificity for MPA, GPA and EGPA
| Test or model | Sensitivity, MPA | Sensitivity, GPA | Sensitivity, EGPA | Specificity, MPA | Specificity, GPA | Specificity, EGPA |
|---|---|---|---|---|---|---|
| 2022 ACR/EULAR criteria | 96.1% | 48.5% | 84.6% | 70.0% | 95.9% | 98.0% |
| Modified criteria | 90.7% | 83.8% | 96.2% | 86.7% | 99.0% | 95.8% |
Sensitivity, MPA
2022 ACR/EULAR criteria96.1%
Modified criteria90.7%
Sensitivity, GPA
2022 ACR/EULAR criteria48.5%
Modified criteria83.8%
Sensitivity, EGPA
2022 ACR/EULAR criteria84.6%
Modified criteria96.2%
Specificity, MPA
2022 ACR/EULAR criteria70.0%
Modified criteria86.7%
Specificity, GPA
2022 ACR/EULAR criteria95.9%
Modified criteria99.0%
Specificity, EGPA
2022 ACR/EULAR criteria98.0%
Modified criteria95.8%
Original publication
Modification of 2022 ACR/EULAR ANCA-associated vasculitis classification criteria in a Japanese cohort (J-CANVAS). Clin Exp Rheumatol. Published 7 July 2025. doi:10.
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