Vasculitis & polymyalgia rheumatica
Seasonal Influence on Development of Antineutrophil Cytoplasmic Antibody–Associated Vasculitis: A Retrospective Cohort Study Conducted at Multiple Institutions in Japan (J-CANVAS)
Authors' conclusion
The onset of AAV was influenced by seasonal variations and was less frequently observed in autumn. In contrast, the occurrence of PR3-ANCA was triggered, not by season, but by rural residency.
Study context
- Population
- Patients with new-onset eosinophilic granulomatosis with polyangiitis (EGPA), microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA) in a Japanese multicentre cohort database (mean age 70.9 years; 55.5% female)
- Participants
- 454 patients
- Exposure
- EGPA vs MPA vs GPA
- EGPAn = 74
- MPAn = 291
- GPAn = 89
- Outcome
- Seasonal differences in AAV onset (4 seasons; Pearson chi-square test vs expected probability of 25% per season)
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
Seasonality of AAV onset
- Seasonality of AAV onset significantly deviated from the expected 25% for each season; onset less frequent in autumn
- P = 0.001
Observational data: associations, not effects.
Further findings
Seasonality of onset by antineutrophil cytoplasmic antibody (ANCA) serotype
- Seasonality significant in MPO-ANCA (n=355)
- P < 0.001
- Seasonality not significant in PR3-ANCA (n=46)
- P = 0.97
Rural residency
- Rural residency associated with PR3-ANCA positivity and biopsy-proven pulmonary vasculitis
Original publication
Seasonal Influence on Development of Antineutrophil Cytoplasmic Antibody–Associated Vasculitis: A Retrospective Cohort Study Conducted at Multiple Institutions in Japan (J-CANVAS). J Rheumatol. Published 1 June 2023. doi:10.
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