Vasculitis & polymyalgia rheumatica
Sex Differences in Clinical Manifestations of Hospitalized Patients With Eosinophilic Granulomatosis With Polyangiitis: A Retrospective Cohort Study
Authors' conclusion
In this Chinese EGPA cohort, male and female patients showed distinct disease phenotypes. Male patients with EGPA had a higher disease activity at diagnosis and required more aggressive treatment for remission induction.
Study context
- Population
- Hospitalized patients with eosinophilic granulomatosis with polyangiitis (EGPA) managed at one hospital, 2007–2020, Chinamale to female ratio 1.4:1
- Participants
- 170 patients
- Exposure
- Male vs female patients with EGPA
- Outcome
- Clinical manifestations by sex
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
- Renal involvement (serum creatinine elevation, proteinuria > 1 g/24 h) more frequent in male patients
- Severe gastrointestinal (GI) involvement more common in male patients
- Female patients had longer allergy duration and higher ratios of allergic rhinitis and asthma
- Male patients had higher BVAS and worse prognosis at diagnosis, with lower proportion of 1996 Five Factor Score = 0
Observational data: associations, not effects.
Further findings
Sex differences by age (≤ 55 vs > 55 years)
- Sex differences in proteinuria > 1 g/24 h, serum creatinine > 150 mmol/L, severe GI involvement and weight loss more significant in patients aged ≤ 55 years than > 55 years
Treatment selection
- Methylprednisolone pulse and CYC administered more frequently to male patients
All-cause mortality and cumulative survival
- Comparable between the sexes
Original publication
Sex Differences in Clinical Manifestations of Hospitalized Patients With Eosinophilic Granulomatosis With Polyangiitis: A Retrospective Cohort Study. J Rheumatol. Published 1 June 2023. doi:10.
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