Vasculitis & polymyalgia rheumatica
Coronary vasospasms and other cardiac manifestations in Eosinophilic Granulomatosis with Polyangiitis: Clinical impact and frequency in a monocentre study of 103 patients
Authors' conclusion
Cardiac involvement is a common initial manifestation of EGPA and is associated with elevated systemic disease activity. In addition to pericarditis and myocarditis, coronary vasospasms were identified as a rare and severe manifestation of EGPA that may mimic myocardial infarction.
Study context
- Population
- Previously untreated patients with eosinophilic granulomatosis with polyangiitis (EGPA) at disease onset, single centre
- Participants
- 103 participants
- Exposure
- EGPA with cardiac involvement vs EGPA without cardiac involvement
- EGPA with cardiac involvement (EGPA-CI)n = 36
- Outcome
- Cardiac manifestations at disease onset
- Follow-up
- Disease onset
Methodological detailsmonocentre
- Monocentre
Main finding
As reported in the abstract
EGPA
35%
36 events
Observational data: associations, not effects.
Further findings
Most common cardiac diagnoses
- Pericarditis
- 77%
- Cardiomyopathy with cardiac failure
- 55%
- Definite myocarditis
- 36%
- Cardiogenic shock
- 14%
- Cardiac arrest
- 6%
Vasospastic coronary arteries causing MI in EGPA-CI
- Vasospastic coronary arteries causing MI
- 8%
Disease activity and prognosis, EGPA-CI
- Significantly higher disease activity and worse prognosis, with elevated median eosinophilic count and CRP
Original publication
Coronary vasospasms and other cardiac manifestations in Eosinophilic Granulomatosis with Polyangiitis: Clinical impact and frequency in a monocentre study of 103 patients. RMD Open. Published 19 November 2025. doi:10.
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