Vasculitis & polymyalgia rheumatica
Risk factors for severe infections during induction therapy of patients with microscopic polyangiitis
Authors' conclusion
MPA is associated with a high risk of severe infections, especially in patients treated with higher dosage glucocorticoid and with a history of chronic lung disease.
Study context
- Population
- Newly diagnosed microscopic polyangiitis (MPA) followed ≥6 months, two tertiary care centres, January 2013–December 2023
- Participants
- 374 participants
- Exposure
- Infection vs non-infection within 6 months of MPA diagnosis
- Infectionn = 97
- Outcome
- Severe infections and their risk factors
- Follow-up
- Within 6 months after the diagnosis
Methodological detailstwo tertiary care centres, multivariable logistic regression
- Two tertiary care centres
- Multivariable logistic regression
Main finding
As reported in the abstract
Severe infections · within 6 months after diagnosis
Infection
25.9%
97
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Infection vs non-infection: higher daily average prednisone dose, more chronic lung disease history, more RTX therapy | P < 0.05 |
Site and pathogen of infection
- Most common site: lung
- 75.23%
- Most prevalent pathogen: bacteria
- 43.1%
Original publication
Risk factors for severe infections during induction therapy of patients with microscopic polyangiitis. Clin Exp Rheumatol. Published 19 November 2025. doi:10.
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